Cholesterol synthesis and absorption by 2H2O and 18O-cholesterol and hypocholesterolemic effect of soy protein.

Wong WW, Hachey DL, Clarke LL, Zhang S
J Nutr. 1995 125 (3 Suppl): 612S-618S

PMID: 7884542 · DOI:10.1093/jn/125.suppl_3.612S

The kinetic behavior of orally ingested 18O-cholesterol was compared with that of orally ingested 13C5-cholesterol in two normocholesterolemic men and the hypocholesterolemic effect of soy protein was demonstrated in 12 hypercholesterolemic men. Our results indicated no difference in the metabolism of orally ingested 18O- and 13C5-cholesterol. The use of 18O-cholesterol and 13C5-cholesterol also allowed simultaneous estimation of fractional rates of cholesterol synthesis using the 2H2O method, which were calculated to be 5.76 and 8.17%/d for the two normocholesterolemic subjects. The percent reduction in plasma cholesterol levels were found to be greater when the hypercholesterolemic men were placed on a soy protein diet than on an animal protein diet.

MeSH Terms (16)

Absorption Anticholesteremic Agents Cholesterol Deuterium Oxide Dietary Proteins Erythrocytes Humans Hypercholesterolemia Kinetics Male Mass Spectrometry Middle Aged Oxygen Isotopes Plant Proteins, Dietary Soybean Proteins Soybeans

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