Dosage compensation of the period gene in Drosophila melanogaster.

Cooper MK, Hamblen-Coyle MJ, Liu X, Rutila JE, Hall JC
Genetics. 1994 138 (3): 721-32

PMID: 7851769 · PMCID: PMC1206222

The period (per) gene is located on the X chromosome of Drosophila melanogaster. Its expression influences biological clocks in this fruit fly, including the one that subserves circadian rhythms of locomotor activity. Like most X-linked genes in Drosophila, per is under the regulatory control of gene dosage compensation. In this study, we assessed the activity of altered or augmented per+ DNA fragments in transformants. Relative expression levels in male and female adults were inferred from periodicities associated with locomotor behavioral rhythms, and by histochemically assessing beta-galactosidase levels in transgenics carrying different kinds of per-lacZ fusion genes. The results suggest that per contains multipartite regulatory information for dosage compensation within the large first intron and also within the 3' half of this genetic locus.

MeSH Terms (13)

Animals Animals, Genetically Modified Circadian Rhythm DNA Dosage Compensation, Genetic Drosophila melanogaster Drosophila Proteins Female Male Nuclear Proteins Period Circadian Proteins Transformation, Genetic X Chromosome

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