Breast feeding in neonatal alloimmune thrombocytopenia.

Reese J, Raghuveer TS, Dennington PM, Barfield CP
J Paediatr Child Health. 1994 30 (5): 447-9

PMID: 7833086 · DOI:10.1111/j.1440-1754.1994.tb00700.x

Infants with neonatal alloimmune thrombocytopenia are at risk of severe intracranial haemorrhage. Placental transfer of maternal immunoglobulin G (IgG) directed against fetal platelet antigens is known to be the underlying mechanism. Since breast milk contains IgG it is theoretically possible that breast feeding of these infants could cause thrombocytopenia. The following case report shows that an infant with neonatal alloimmune thrombocytopenia may be safely breast fed, even when the breast milk contains the platelet specific antibody (HPA-1a).

MeSH Terms (12)

Antigens, Human Platelet Breast Feeding Female Fetal Blood Humans Immunoglobulin G Infant, Newborn Isoantibodies Male Milk, Human Pregnancy Thrombocytopenia

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