Contraction of isolated porcine coronary arteries is inhibited by high concentrations of propranolol.

Carey EL, Robertson D, Wells JN, Robertson RM
Angiology. 1995 46 (6): 453-60

PMID: 7785786 · DOI:10.1177/000331979504600601

Isometric tension responses of isolated porcine coronary artery rings were studied in the presence of concentrations of propranolol higher than those necessary to block effects mediated by beta-adrenergic receptors. Propranolol (50-300 microM) inhibited contractions induced by 30 mM KCl and by histamine, norepinephrine, and acetylcholine in a concentration-dependent, noncompetitive fashion. The (+) propranolol isomer and the racemic mixture were equipotent inhibitors of contraction. Propranolol inhibition was partly reversed by increased extracellular Ca++. These effects of propranolol thus appeared to be independent of beta-blockade and could be relevant to some of the drug's observed but still unexplained in vivo actions.

MeSH Terms (12)

Acetylcholine Animals Coronary Vessels Depression, Chemical Dose-Response Relationship, Drug Histamine Histamine Antagonists In Vitro Techniques Norepinephrine Propranolol Swine Vasoconstriction

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