Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2.

Wilborn J, Crofford LJ, Burdick MD, Kunkel SL, Strieter RM, Peters-Golden M
J Clin Invest. 1995 95 (4): 1861-8

PMID: 7706493 · PMCID: PMC295728 · DOI:10.1172/JCI117866

MeSH Terms (21)

Base Sequence Cells, Cultured Dinoprostone Eicosanoids Female Fibroblasts Humans Immunoblotting Interleukin-1 Intramolecular Oxidoreductases Isomerases Lipopolysaccharides Lung Male Molecular Sequence Data Polymerase Chain Reaction Prostaglandin-Endoperoxide Synthases Prostaglandin-E Synthases Pulmonary Fibrosis RNA, Messenger Tetradecanoylphorbol Acetate

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