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A link between increased transforming activity of lymphoma-derived MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc transactivation domain.

Hoang AT, Lutterbach B, Lewis BC, Yano T, Chou TY, Barrett JF, Raffeld M, Hann SR, Dang CV
Mol Cell Biol. 1995 15 (8): 4031-42

PMID: 7623799 · PMCID: PMC230642 · DOI:10.1128/MCB.15.8.4031

MeSH Terms (24)

Alleles Amino Acid Sequence Base Sequence Burkitt Lymphoma Cell Transformation, Neoplastic Cyclins DNA-Binding Proteins Gene Expression Regulation, Neoplastic Genes, myc Humans Models, Genetic Molecular Sequence Data Mutation Nuclear Proteins Phosphorylation Protein Binding Proto-Oncogene Proteins c-myc Retinoblastoma-Like Protein p107 Structure-Activity Relationship Suppression, Genetic TATA-Box Binding Protein Threonine Transcriptional Activation Transcription Factors

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