Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype.

Threadgill DW, Dlugosz AA, Hansen LA, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC
Science. 1995 269 (5221): 230-4

PMID: 7618084 · DOI:10.1126/science.7618084

Gene targeting was used to create a null allele at the epidermal growth factor receptor locus (Egfr). The phenotype was dependent on genetic background. EGFR deficiency on a CF-1 background resulted in peri-implantation death due to degeneration of the inner cell mass. On a 129/Sv background, homozygous mutants died at mid-gestation due to placental defects; on a CD-1 background, the mutants lived for up to 3 weeks and showed abnormalities in skin, kidney, brain, liver, and gastrointestinal tract. The multiple abnormalities associated with EGFR deficiency indicate that the receptor is involved in a wide range of cellular activities.

MeSH Terms (22)

Abnormalities, Multiple Animals Base Sequence Brain Cell Division Digestive System Digestive System Abnormalities Embryonic and Fetal Development ErbB Receptors Female Gene Targeting Hair Homozygote Kidney Lung Male Mice Molecular Sequence Data Mutation Phenotype Skin Skin Abnormalities

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