The roles of retinoids in vertebrate development.

Means AL, Gudas LJ
Annu Rev Biochem. 1995 64: 201-33

PMID: 7574480 · DOI:10.1146/

Several lines of experimentation suggest that endogenous retinoids, metabolites of vitamin A, play a role in the anterior/posterior development of the central body axis and the limbs of vertebrates. High levels of endogenous retinoids have been detected in proximity to these developing axes in a variety of vertebrate fetuses. Teratogenesis studies suggest that both retinoid excess and deficiency are capable of disrupting the development of these axes. Finally, retinoic acid receptors regulate many developmental control genes, including homeobox genes and growth factor genes.

MeSH Terms (10)

Animals Carrier Proteins Embryonic and Fetal Development Genes, Homeobox Growth Substances Humans Molecular Structure Receptors, Retinoic Acid Retinoids Teratogens

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