Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression.

Olson LK, Sharma A, Peshavaria M, Wright CV, Towle HC, Rodertson RP, Stein R
Proc Natl Acad Sci U S A. 1995 92 (20): 9127-31

PMID: 7568086 · PMCID: PMC40937 · DOI:10.1073/pnas.92.20.9127

MeSH Terms (23)

3T3 Cells Animals Base Sequence Blotting, Northern Cell Line Cell Nucleus Chloramphenicol O-Acetyltransferase DNA Primers Gene Expression Glucose Homeodomain Proteins Humans Insulin Islets of Langerhans Mice Molecular Sequence Data Polymerase Chain Reaction Protein Biosynthesis Recombinant Proteins RNA, Messenger Trans-Activators Transcription, Genetic Transcription Factors

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