Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin-1: a potential mechanism for inflammatory angiogenesis.

Ben-Av P, Crofford LJ, Wilder RL, Hla T
FEBS Lett. 1995 372 (1): 83-7

PMID: 7556649 · DOI:10.1016/0014-5793(95)00956-a

Inflammatory mediators such as prostaglandin E2 (PGE2) and interleukin-1 (IL-1) induce angiogenesis by yet undefined mechanisms. We demonstrate that PGE2 and IL-1 induces the expression of vascular endothelial growth factor (VEGF), a selective angiogenic factor by rheumatoid synovial fibroblast cells. Transcripts for the EP1 and EP2 subtypes of PGE receptors are expressed in synovial fibroblasts. Activators of protein kinase A pathway stimulated the expression of VEGF whereas down-regulation of protein kinase C did not influence the PGE effect, suggesting that signalling from the EP2 receptor via the protein kinase A pathway is important. The induction of VEGF expression by PGE2 and interleukin-1 alpha may be an important mechanism in inflammatory angiogenesis.

MeSH Terms (22)

Arthritis, Rheumatoid Bacterial Toxins Base Sequence Colforsin Cyclic AMP-Dependent Protein Kinases DNA Primers Endothelial Growth Factors Fibroblasts Gene Expression Regulation Humans Interleukin-1 Lymphokines Molecular Sequence Data Neovascularization, Pathologic Prostaglandins E Protein Kinase C Receptors, Prostaglandin E Signal Transduction Synovial Fluid Tetradecanoylphorbol Acetate Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors

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