Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

Rickert RC, Rajewsky K, Roes J
Nature. 1995 376 (6538): 352-5

PMID: 7543183 · DOI:10.1038/376352a0

CD19 is the hallmark differentiation antigen of the B lineage. Its early expression has implicated a role for CD19 during the antigen-independent phases of B-cell development, whereas in mature B cells CD19 can act synergistically with surface immunoglobulin to induce activation. We have generated CD19-deficient mice and found that development of conventional B cells is unperturbed. However, mature CD19-/- B cells show a profound deficiency in responding to protein antigens that require T-cell help. This is accompanied by a lack of germinal centre formation and affinity maturation of serum antibodies. Thus CD19 is crucial for both initial B-cell activation by T-cell-dependent antigens and the maturation and/or selection of the activated cells into the memory compartment. An impairment in ligand-driven selection may also be responsible for the observation of a striking reduction in the B-1 (formerly Ly-1) B-cell subset, thought to develop under the control of self-antigens and bacterial antigens (reviewed in ref. 2).

MeSH Terms (22)

Animals Antigens Antigens, CD Antigens, CD19 Antigens, Differentiation, B-Lymphocyte B-Lymphocytes B-Lymphocyte Subsets Base Sequence Bone Marrow Cells Cell Differentiation Cells, Cultured DNA Primers Flow Cytometry Hematopoietic Stem Cells Lymphocyte Activation Mice Mice, Inbred BALB C Molecular Sequence Data Mutagenesis Peritoneal Cavity Spleen T-Lymphocytes

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