Detection of T cells responsive to a vascular growth factor in rheumatoid arthritis.

Byrd VM, Zhao XM, Miller GG, Thomas JW
Immunol Res. 1994 13 (2-3): 139-44

PMID: 7539824

The primary lesion in rheumatoid arthritis (RA) is a destructive synovitis characterized by proliferation of endothelial cells, fibroblasts, and vascular smooth muscle cells, and with perivascular lymphocyte aggregates. A nonhematopoietic growth factor, acidic fibroblast growth factor (aFGF), may induce many of the biological features found in rheumatoid synovium, including T cell activation. To determine if aFGF-responsive T cells are increased in RA, we developed an assay to measure the frequency of peripheral blood T cells that are costimulated by aFGF. The data indicate that the frequency of aFGF-responsive T cells is increased in RA and may change with disease activity and treatment.

MeSH Terms (7)

Arthritis, Rheumatoid Cells, Cultured Fibroblast Growth Factor 1 Humans Immunologic Tests Lymphocyte Activation T-Lymphocytes

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