Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion.

Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N
Proc Natl Acad Sci U S A. 1994 91 (6): 2051-5

PMID: 7510884 · PMCID: PMC43307 · DOI:10.1073/pnas.91.6.2051

MeSH Terms (17)

Animals Base Sequence Diabetes Mellitus, Type 2 Disease Models, Animal DNA Glucokinase Glucose Immunohistochemistry Insulin Insulin Secretion Islets of Langerhans Mice Mice, Transgenic Molecular Sequence Data Nucleic Acid Conformation RNA RNA, Catalytic

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