Cold-passaged, temperature-sensitive mutants of human respiratory syncytial virus (RSV) are highly attenuated, immunogenic, and protective in seronegative chimpanzees, even when RSV antibodies are infused shortly before immunization.

Crowe JE, Bui PT, Siber GR, Elkins WR, Chanock RM, Murphy BR
Vaccine. 1995 13 (9): 847-55

PMID: 7483808 · DOI:10.1016/0264-410x(94)00074-w

MeSH Terms (20)

Animals Antibodies, Viral Cell Line, Transformed Chlorocebus aethiops Cold Temperature Female Humans Immunization, Passive Male Mice Mice, Inbred BALB C Mutation Neutralization Tests Pan troglodytes Respiratory Syncytial Viruses Serial Passage Vaccines, Attenuated Vero Cells Viral Vaccines Virus Replication

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