Arachidonic acid 15-lipoxygenase products from human eosinophils.

Turk J, Maas RL, Brash AR, Roberts LJ, Oates JA
J Biol Chem. 1982 257 (12): 7068-76

PMID: 6806264

A series of six derivatives of arachidonic acid containing a conjugated triene system and hydroxyl groups at C-15 and at C-8 or C-14 (15-series leukotrienes) was isolated from eosinophil-rich human leukocyte preparations. Among classes of leukocytes in these preparations, eosinophils were the dominant source of the 15-series leukotrienes. The most abundant arachidonate metabolite recovered from human eosinophils was 15(S)-hydroxy-5,8,11-cis-13-trans-eicosatetraenoic acid. This compound was synthesized by a lipoxygenase enzyme and is a reduction product of the precursor to the 15-series leukotrienes (15(S)-hydroperoxy-5,8,11-cis-13-trans-eicosatetraenoic acid).

MeSH Terms (9)

Arachidonate Lipoxygenases Arachidonic Acids Eosinophilia Eosinophils Humans Lipoxygenase Mass Spectrometry Reference Values Spectrophotometry, Ultraviolet

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