An acidic extracellular environment reduces the fixation of radiation damage.

Freeman ML, Sierra E
Radiat Res. 1984 97 (1): 154-61

PMID: 6695039

Chinese hamster ovary cells in exponential growth were irradiated with gamma or X rays in an acidic or alkaline extracellular environment. Incubation in acid medium during or after irradiation reduced the degree of fixation of potentially lethal lesions. Fixation and repair of acid-modified damage occurred with a halftime of 9 to 10 min. The rate of repair of sublethal damage was unaffected by hydrogen ion concentration and progressed with a half-time of 30 min. An acid environment modified only survival of exponentially growing cells; unfed plateau-phase cultures were unaffected.

MeSH Terms (12)

Animals Cells, Cultured Cell Survival Cricetinae Cricetulus Culture Media Dose-Response Relationship, Radiation Female Gamma Rays Hydrogen-Ion Concentration Ovary Time Factors

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