The repair of sublethal damage in diploid human fibroblasts: a comparison between human and rodent cell lines.

Freeman ML, Sierra E, Hall EJ
Radiat Res. 1983 95 (2): 382-91

PMID: 6611855

Two diploid cell lines of human origin were irradiated in vitro. Repair of sublethal damage was observed in both lines when they were exposed to a single gamma-ray dose and incubated at 37 degrees C prior to receiving a graded second dose. In addition cells were irradiated at a low dose rate (56 or 76 rad/hr) and survival was compared to that after an acute exposure. A dose-rate effect was demonstrated. Sublethal damage repair was also studied using CHO or V-79 Chinese hamster cells, and the data suggest that the degree of repair is similar in human and rodent cell lines at photon doses up to 500 rad. The repair of sublethal damage can be a significant factor in the survival of human cells in vitro for fractionated doses.

MeSH Terms (10)

Animals Cell Line Cell Survival Cesium Radioisotopes Cricetinae Cricetulus DNA Repair Dose-Response Relationship, Radiation Gamma Rays Humans

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