Glycine N-methyltransferase is a folate binding protein of rat liver cytosol.

Cook RJ, Wagner C
Proc Natl Acad Sci U S A. 1984 81 (12): 3631-4

PMID: 6587377 · PMCID: PMC345272 · DOI:10.1073/pnas.81.12.3631

A comparison of the amino acid compositions of one of the folate-binding proteins of rat liver cytosol, folate-binding protein-cytosol II, and that of glycine N-methyltransferase (S-adenosyl-L-methionine:glycine methyltransferase, EC from the same source indicated a great deal of structural homology between the two proteins. Antiserum prepared against the purified folate-binding protein almost completely inactivated the enzyme activity in crude liver cytosol. Purification of glycine N-methyltransferase resulted in the separation of two enzyme species, one that contained bound folate and one that did not. Each species was homogeneous, as judged by NaDodSO4/polyacrylamide gel electrophoresis, and they migrated identically.

MeSH Terms (12)

Amino Acids Animals Carrier Proteins Cytosol Folate Receptors, GPI-Anchored Folic Acid Glycine N-Methyltransferase Liver Male Methyltransferases Rats Receptors, Cell Surface

Connections (1)

This publication is referenced by other Labnodes entities: