Selective 5HT-2 antagonists inhibit serotonin stimulated phosphatidylinositol metabolism in cerebral cortex.

Conn PJ, Sanders-Bush E
Neuropharmacology. 1984 23 (8): 993-6

PMID: 6483122 · DOI:10.1016/0028-3908(84)90017-0

Evidence suggests that the serotonin 5HT-1 receptor site is functionally linked to adenylate cyclase in the brain, but a biochemical effector system which is linked to the serotonin 5HT-2 receptor site has not been found. In the present paper we report an investigation of 5HT stimulated phosphatidylinositol (PI) hydrolysis in rat cerebral cortex and have found that selective 5HT-2 antagonists (pizotifen and ketanserin) block 5HT's effect upon PI metabolism. These data suggest that 5HT stimulated PI hydrolysis is mediated by the 5HT-2 binding site.

MeSH Terms (10)

Animals Cerebral Cortex In Vitro Techniques Ketanserin Phosphatidylinositols Piperidines Pizotyline Rats Serotonin Serotonin Antagonists

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