Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.

Wieslander J, Barr JF, Butkowski RJ, Edwards SJ, Bygren P, HeinegÄrd D, Hudson BG
Proc Natl Acad Sci U S A. 1984 81 (12): 3838-42

PMID: 6328527 · PMCID: PMC345316 · DOI:10.1073/pnas.81.12.3838

The glomerular basement membrane antigen in Goodpasture syndrome is a collagenase-resistant molecule with a monomer molecular weight of about 26,000. Type IV collagen isolated from glomerular basement membrane contains collagenase-resistant sequences within its structure. Polyacrylamide gel electrophoresis, enzyme-linked immunosorbent assay, and chemical analysis were used to demonstrate that the collagenase-resistant sequences of type IV collagen contain Goodpasture antigen.

MeSH Terms (8)

Anti-Glomerular Basement Membrane Disease Autoimmune Diseases Basement Membrane Collagen Humans Kidney Glomerulus Microbial Collagenase Molecular Weight

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