Evaluation of transsphenoidal hypophysectomy in the management of patients with advanced malignant melanoma.

Lawson DH, Nixon DW, Black ML, Tindall GT, Barnes DA, Faraj BA, Ali FM, Camp VM, Richmond A
Cancer. 1983 51 (8): 1541-5

PMID: 6186359 · DOI:10.1002/1097-0142(19830415)51:8<1541::aid-cncr2820510831>3.0.co;2-s

Transsphenoidal hypophysectomy was performed in 13 patients with advanced malignant melanoma. Although three minor responses were observed, there were no complete or partial responses. All three patients with bone pain had a decrease in discomfort lasting 1-2 months. All five patients with minor responses or stable disease had postoperative decreases in the excretion of the dihydroxyphenylalanine (DOPA) metabolite 3-O-methyldopamine; all but one patient with clinical progression had postoperative increases in excretion. Average survival of those whose postoperative excretion fell (143 +/- days; range, 60-217+) was significantly longer (P less than 0.004) than that of those whose postsurgical values rose (30 days; range, 15-58).

MeSH Terms (16)

Adult Evaluation Studies as Topic Female Humans Hypophysectomy Male Melanoma Methyltyrosines Middle Aged Neoplasm Metastasis Palliative Care Postoperative Complications Prognosis Radioimmunoassay Skin Neoplasms Tyrosine

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