Cross-reactivity between human and murine lymphocyte antigens. IV. Reactivity of H-2 alloantisera with HLA-A, B antigens.

Quaranta V, Pellegrino MA, Callahan GN, Ferrone S
Immunogenetics. 1981 13 (4): 311-7

PMID: 6168581 · DOI:10.1007/BF00364496

The anti-H-2 alloantiserum D-32 [(B10.A(2R) x C3H.SW) anti-C3H] is cytolytic to human lymphocytes. Fab2 blocking assays, indirect immunoprecipitation and sequential immunoprecipitation experiments showed that the anti-H-2 alloantiserum D-32 recognizes antigenic determinants which are expressed on the heavy chain of subpopulations of HLA-A, B antigens. These determinants are different from those defining the serological polymorphism of the HLA-A, B, C system, are the same as or spatially close to those recognized by the anti-HLA-A, B monoclonal antibody Q6/64 and are expressed on rabbit, rat or guinea pig lymphocytes.

MeSH Terms (12)

Animals Cross Reactions Epitopes Guinea Pigs H-2 Antigens HLA Antigens Humans Isoantibodies Mice Rabbits Rats Species Specificity

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