Distribution of antigenic determinants recognized by three monoclonal antibodies (Q2/70, Q5/6 and Q5/13) on human Ia-like alloantigens and on their subunits.

Quaranta V, Tanigaki N, Ferrone S
Immunogenetics. 1981 12 (1-2): 175-82

PMID: 6162791 · DOI:10.1007/bf01561660

The distribution of antigenic determinants recognized by the anti-Ia-like antigen monoclonal antibodies (MoAb) Q2/70, Q5/6 and Q5/13 on molecules coded for by the DR locus and by non-DR loci was investigated using a binding assay with 125I-labeled Ia-like antigens isolated from four B lymphoid cell lines. The determinants reacting with the MoAb Q2/70 and Q5/13 are expressed on all DR alloantigens tested and on BR4X7 specificities, while those reacting with the MoAb Q5/6 are not detectable on DRw7 and BR4X7 molecules. None of the monoclonal antibodies reacted with DC1 molecules. The MoAb Q5/6 and Q5/13 reacted with the isolated beta subunit of the Ia-like antigenic complex, while the MoAb Q2/70 did not react with the isolated chains.

MeSH Terms (14)

Animals Antibodies Antigen-Antibody Complex Binding Sites, Antibody Chromosome Mapping Clone Cells Epitopes Genetic Code Goats Histocompatibility Antigens Class II Humans Immune Sera Mice Rabbits

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