Serologic and immunochemical characterization of the specificity of four monoclonal antibodies to distinct antigenic determinants expressed on subpopulations of human Ia-like antigens.

Quaranta V, Pellegrino MA, Ferrone S
J Immunol. 1981 126 (2): 548-52

PMID: 6161181

Serologic and immunochemical assays showed that the monoclonal antibodies Q2/70, Q2/80, Q5/6, and Q5/13 react with human Ia-like antigens. Each monoclonal antibody recognizes distinct antigenic determinants that are different from those defining the serologic polymorphism of Ia-like antigens defined by conventional alloantisera and are expressed on subpopulations of Ia-like antigens. The determinants recognized by the MoAb Q2/70 and Q5/13 are expressed on all HLA-DR allospecificities tested, whereas those reacting with the MoAb Q2/80 and Q5/6 are not detectable on HLA-DR5 and HLA-DR7 allospecificities, respectively.

MeSH Terms (10)

Antibodies Antibody Specificity Binding, Competitive Binding Sites, Antibody Cell Line Clone Cells Epitopes Histocompatibility Antigens Class II Humans Hybrid Cells

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