Purification of immunologically functional subsets of human Ia-like antigens on a monoclonal antibody (Q5/13) immunoadsorbent.

Quaranta V, Walker LE, Pellegrino MA, Ferrone S
J Immunol. 1980 125 (4): 1421-5

PMID: 6157732

Serologic and immunochemical asays have shown that the monoclonal antibody Q5/13 recognizes an antigenic determinant expressed on a subset of human Ia-like antigens. Testing with a panel of HLA typed B lymphoid cells has shown that this determinant is different from those defining the serologic polymorphism of HLA-DR antigens. The monoclonal antibody Q5/13 has been used to purify subsets of human Ia-like antigens, which are immunologically functional. These reagents should facilitate the characterization of structural and functional properties of human Ia-like antigens.

MeSH Terms (10)

Antibodies Antigen-Antibody Complex B-Lymphocytes Clone Cells Cytotoxicity, Immunologic Epitopes Histocompatibility Antigens Class II Humans Immunosorbents Molecular Weight

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