Systemic prostaglandin I2 synthesis is normal in patients with Bartter's syndrome.

Watson ML, Gill JR, Branch RA, Oates JA, Brash AR
Lancet. 1983 2 (8346): 368-70

PMID: 6135873 · DOI:10.1016/s0140-6736(83)90344-6

Urinary excretion of 2, 3 dinor-6-keto-PGF1 alpha, a metabolite of prostacyclin (PGI2), was measured in 9 patients with Bartter's syndrome. The rate of excretion of this metabolite was normal in these patients during ingestion of both a normal and high dietary intake of potassium. This suggests that in Bartter's syndrome the rate of entry of PGI2 into the circulation is normal. Excessive systemic synthesis of PGI2 is therefore unlikely to be an explanation for either the vascular insensitivity to angiotensin II or the defect in platelet aggregation characteristic of the syndrome.

MeSH Terms (20)

6-Ketoprostaglandin F1 alpha Adolescent Adult Aldosterone Bartter Syndrome Child Chlorides Epoprostenol Female Humans Hyperaldosteronism Kidney Loop of Henle Male Middle Aged Platelet Aggregation Potassium Prostaglandins Renin Sodium

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