Induced ovulation in aged female rats by L-dopa implants into the medial preoptic area.

Cooper RL, Brandt SJ, Linnoila M, Walker RF
Neuroendocrinology. 1979 28 (4): 234-40

PMID: 571539 · DOI:10.1159/000122867

Direct placement of L-dopa into the medial preoptic area (MPOA) of aged pseudopregnant or constant vaginal estrous female rats resulted in a reinitiation of vaginal cycles and ovulation. Similar treatment with L-dopa in the dorsomedial septum or cortex was ineffective. Direct placement of leucine into any of the three brain regions did not have an effect on ovarian function. Intermittent treatment with L-dopa to MPOA was found to reinstate and maintain vaginal cycles in constant estrous females only when administered on the day of vaginal estrus of successive cycles. These findings support the hypothesis that age-dependent disturbances in ovarian function may be initiated by changes in neurotransmitter metabolism within the central nervous system.

MeSH Terms (15)

Age Factors Animals Brain Mapping Drug Implants Estrus Female Hypothalamus Levodopa Ovulation Pregnancy Preoptic Area Rats Septum Pellucidum Stimulation, Chemical Temporal Lobe

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