Effects of diethylcholine in two animal models of Parkinsonism tremors.

Matthews RT, Chiou CY
Eur J Pharmacol. 1979 56 (1-2): 159-62

PMID: 467505 · DOI:10.1016/0014-2999(79)90446-1

(2-Hydroxyethyl) methyldiethylammonium iodide (diethylcholine; DEC) was tested against trihexyphenidyl for its ability to block tremors in two animal models of Parkinsonism tremors. Both DEC (75 mg/kg) and trihexyphenidyl (10 mg/kg) antagonized physostigmine tremors in mice. Both drugs also blocked tremors in rats which received intracaudate injections of carbachol. DEC was more efficacious than trihexyphenidyl in the rat model. No dose-related inhibition of tremors was seen for trihexyphenidyl (5--20 mg/kg) but inhibition by DEC was dose-related (25--50 mg/kg). The ED50 for tremor inhibition in the rat model by DEC was 33 mg/kg. DEC was also shown to cross the blood-brain barrier in mice. The probable mechanism of action of DEC is discussed.

MeSH Terms (11)

Animals Brain Chemistry Carbachol Choline Disease Models, Animal Male Mice Parkinson Disease, Secondary Physostigmine Rats Trihexyphenidyl

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