Formaldehyde kinetics and bacteriology in dialyzers.

Hakim RM, Friedrich RA, Lowrie EG
Kidney Int. 1985 28 (6): 936-43

PMID: 4087700 · DOI:10.1038/ki.1985.221

The kinetics of formaldehyde washout in new and reused dialyzers with 2% (w/v) and 4% formaldehyde solution was studied. Using a standard method of rinsing, the concentration of formaldehyde decreases exponentially, but the rate of decrease and the steady-state level depends on the type of dialyzer. The residual quantity of formaldehyde using a 4% solution is more than twice that seen with a 2% solution in similar dialyzers. Bacteriological tests on water-adapted, formaldehyde-resistant organisms indicate that a significant proportion of these organisms can survive a 4-hr incubation with 4% formaldehyde at 20 degrees C. However, increasing the temperature of incubation to 40 degrees C or the addition of ethanol up to 8% (v/v) improved the bacteriological efficacy of formaldehyde. Under these conditions, a 1% formaldehyde solution allows eradication of all organisms tested. Similar results were observed in multiple-use dialyzers inoculated with the same organisms. There was no effect of incubation at 40 degrees C on the in vitro clearance determinations of new and reused dialyzers.

MeSH Terms (8)

Disinfection Formaldehyde Humans Kidneys, Artificial Kinetics Microbial Sensitivity Tests Statistics as Topic Sterilization

Connections (1)

This publication is referenced by other Labnodes entities: