Human growth hormone induces and maintains c-myc gene expression in Nb2 lymphoma cells.

Fleming WH, Murphy PR, Murphy LJ, Hatton TW, Matusik RJ, Friesen HG
Endocrinology. 1985 117 (6): 2547-9

PMID: 4065045 · DOI:10.1210/endo-117-6-2547

The effect of human GH (hGH) on c-myc gene expression and cell proliferation in the Nb2 lymphoma cell line was examined. The addition of hormone to stationary cultures of Nb2 cells resulted in an increased accumulation of c-myc transcripts that was detectable within 15 min, reached a maximum induction of 25-fold in 3 h, and then gradually declined. Although maximal accumulation of c-myc transcripts occurred within 3 h after hGH addition, removal of the hormone even after 4 h of treatment resulted in a failure of the cells to proliferate. This loss of proliferative capacity following hormone removal was accompanied by a 20-fold reduction in the level of c-myc transcripts. These results indicate that hGH induced proliferation of Nb2 cells is associated with the induction and maintenance of c-myc gene expression.

MeSH Terms (9)

Cell Division Cell Line Gene Expression Regulation Growth Hormone Humans Lymphoma Oncogenes RNA, Messenger Time Factors

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