Distinct patterns of expression of different protein kinase C mRNAs in rat tissues.

Brandt SJ, Niedel JE, Bell RM, Young WS
Cell. 1987 49 (1): 57-63

PMID: 3829128 · DOI:10.1016/0092-8674(87)90755-0

The identification of multiple protein kinase C (PKC) cDNA sequences from rat, bovine, and human tissues has led to the discovery of a family of PKC genes. Using probes complementary to three cDNA sequences from rat brain, designated PKC-I, -II, and -III, the distribution of PKC transcripts in rat tissues was studied by in situ hybridization histochemistry. In brain, PKC-II and PKC-III transcripts colocalized except in the brain stem and spinal cord, where some cells appeared to contain only PKC-III message. PKC-I mRNA had a different, but partially overlapping, pattern of expression. In spleen, PKC-II and PKC-III, but not PKC-I, transcripts were concentrated in the marginal zone of white pulp, the major B-lymphocyte compartment of rat spleen. The distinct distributions of rat PKC mRNAs suggest that different members of the PKC family have specialized functions.

MeSH Terms (11)

Animals Brain Cloning, Molecular DNA Humans Nucleic Acid Hybridization Organ Specificity Protein Kinase C RNA, Messenger Species Specificity Transcription, Genetic

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