Denervation supersensitivity of 5-HT-1c receptors in rat choroid plexus.

Conn PJ, Janowsky A, Sanders-Bush E
Brain Res. 1987 400 (2): 396-8

PMID: 3815085 · DOI:10.1016/0006-8993(87)90641-x

Serotonin (5-HT)-stimulated phosphoinositide hydrolysis in the choroid plexus is mediated by the 5-HT-1c receptor. The current study demonstrates that treatment of rats with the serotonergic neurotoxin, 5,7-dihydroxytryptamine, caused a marked depletion of 5-HT and a supersensitive 5-HT-1c mediated phosphoinositide hydrolysis response. These data suggest that the 5-HT-1c site in choroid plexus receives tonic serotonergic input.

MeSH Terms (12)

5,7-Dihydroxytryptamine Animals Choroid Plexus Denervation Hydrolysis Inositol Phosphates Male Osmolar Concentration Rats Rats, Inbred Strains Receptors, Serotonin Serotonin

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