Combined 1H and 31P nuclear magnetic resonance spectroscopic studies of bicuculline-induced seizures in vivo.

Petroff OA, Prichard JW, Ogino T, Avison M, Alger JR, Shulman RG
Ann Neurol. 1986 20 (2): 185-93

PMID: 3752964 · DOI:10.1002/ana.410200203

Using a 1.89-Tesla spectrometer, 1H and 31P nuclear magnetic resonance spectra were acquired from the brains of paralyzed rabbits ventilated with 30% oxygen in nitrous oxide. Intracellular pH and changes in lactate concentration in the cerebrum were monitored by nuclear magnetic resonance methods during and after bicuculline-induced seizures, together with the electroencephalogram, heart rate, and arterial blood pressure. During seizures lasting more than an hour, cerebral intracellular pH became acidic, the cerebral lactate level rose rapidly, and both changes persisted as long as 2 hours without signs of recovery. After less prolonged seizures, lactate elevations were no less persistent, despite nearly complete recovery of intracellular pH and the electroencephalogram.

MeSH Terms (14)

Animals Bicuculline Blood Pressure Electroencephalography Female Heart Rate Hydrogen Hydrogen-Ion Concentration Lactates Lactic Acid Magnetic Resonance Spectroscopy Phosphorus Rabbits Status Epilepticus

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