Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil.

Konradi C, Jellinger K, Riederer P, Nagatsu T
J Neural Transm. 1987 70 (3-4): 369-76

PMID: 3681291 · DOI:10.1007/BF01253611

A coupled peroxidation technique for localization of monoamine oxidase (MAO-A and MAO-B), applied to post-mortem fixed tissue of the locus coeruleus of the Mongolian gerbil is demonstrated. Tyramine hydrochloride, beta-phenylethylamine and 5-hydroxytryptamine creatinine sulphate were used as substrates, 1-deprenyl and clorgyline served as specific inhibitors. All three substrates stained the neurons of locus coeruleus in the absence of inhibitor. In the presence of 1-deprenyl, tyramine hydrochloride and 5-hydroxytryptamine creatinine sulphate were metabolized, whereas in the presence of clorgyline no reaction with either substrate could be observed. Immunocytochemical staining of tyrosine hydroxylase (TH) was employed as comparison.

MeSH Terms (5)

Animals Gerbillinae Histocytochemistry Locus Coeruleus Monoamine Oxidase

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