Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis.

Harrison DG, Armstrong ML, Freiman PC, Heistad DD
J Clin Invest. 1987 80 (6): 1808-11

PMID: 3680531 · PMCID: PMC442458 · DOI:10.1172/JCI113276

Atherosclerosis results in impaired relaxation to acetylcholine, thrombin, and the calcium ionophore A23187, all agents that require the presence of endothelium. We now report that dietary treatment of atherosclerosis in monkeys not only produces morphological improvement of the atherosclerotic lesion but restores endothelium-dependent vascular relaxation to normal. Because the intima remains thickened after regression of atherosclerosis, these studies suggest that intimal thickening which is present in both atherosclerotic vessels and after regression of atherosclerosis does not prevent the endothelium-derived relaxing factor from reaching the underlying vascular smooth muscle.

MeSH Terms (8)

Animals Arteriosclerosis Endothelium, Vascular Iliac Artery Macaca fascicularis Muscle, Smooth Muscle Contraction Muscle Relaxation

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