Calcitonin gene-related peptide in the ventral tegmental area: selective modulation of prefrontal cortical dopamine metabolism.

Deutch AY, Roth RH
Neurosci Lett. 1987 74 (2): 169-74

PMID: 3554009 · DOI:10.1016/0304-3940(87)90144-3

The distribution of calcitonin gene-related peptide (CGRP) in the A10 dopamine (DA) cell group region of the ventral tegmental area (VTA) of the rat was examined using immunohistochemical techniques. CGRP-like immunoreactivity was localized to axons innervating the rostral and dorsal VTA. Direct administration of CGRP to the VTA of the rat resulted in a dose-related increase in DA utilization in the medial prefrontal cortex, but not other mesocortical, mesolimbic, or striatal DA terminal field regions. These data suggest that CGRP may function to selectively modulate the activity of VTA dopaminergic neurons which innervate the prefrontal cortex.

MeSH Terms (13)

3,4-Dihydroxyphenylacetic Acid Animals Calcitonin Gene-Related Peptide Cerebral Cortex Corpus Striatum Dopamine Frontal Lobe Immunoenzyme Techniques Limbic System Neural Pathways Neuropeptides Rats Tegmentum Mesencephali

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