Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.

Walker EM, Cha J, Tong X, Guo M, Liu JH, Yu S, Iacovazzo D, Mauvais-Jarvis F, Flanagan SE, Korbonits M, Stafford J, Jacobson DA, Stein R
Cell Rep. 2021 37 (2): 109813

PMID: 34644565 · PMCID: PMC8845126 · DOI:10.1016/j.celrep.2021.109813

MeSH Terms (21)

Animals Animals, Genetically Modified Blood Glucose Calcium Signaling Cell Line Cellular Senescence Diabetes Mellitus, Type 2 Disease Models, Animal DNA Damage Female Genetic Predisposition to Disease Humans Insulin Insulin-Secreting Cells Maf Transcription Factors, Large Male Mice, Inbred C57BL Mutation, Missense Phenotype Sex Characteristics Sex Factors

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