The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling.

Shen C, Nayak A, Neitzel LR, Adams AA, Silver-Isenstadt M, Sawyer LM, Benchabane H, Wang H, Bunnag N, Li B, Wynn DT, Yang F, Garcia-Contreras M, Williams CH, Dakshanamurthy S, Hong CC, Ayad NG, Capobianco AJ, Ahmed Y, Lee E, Robbins DJ
Nat Commun. 2021 12 (1): 5263

PMID: 34489457 · PMCID: PMC8421366 · DOI:10.1038/s41467-021-25634-z

MeSH Terms (19)

Adaptor Proteins, Signal Transducing Animals Casein Kinase Ialpha Drosophila melanogaster Drosophila Proteins Embryo, Nonmammalian Evolution, Molecular HEK293 Cells Humans Immunologic Factors Lenalidomide Mice Organoids Peptide Hydrolases Ubiquitin-Protein Ligases Ubiquitination Wnt Signaling Pathway Zebrafish Zebrafish Proteins

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