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Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction.

Palmer ND, Kahali B, Kuppa A, Chen Y, Du X, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Guo X, Smith AV, Ryan KA, Eirksdottir G, Allison MA, Bowden DW, Budoff MJ, Carr JJ, Chen YI, Taylor KD, Correa A, Crudup BF, Halligan B, Yang J, Kardia SLR, Launer LJ, Fu YP, Mosley TH, Norris JM, Terry JG, O'Donnell CJ, Rotter JI, Wagenknecht LE, Gudnason V, Province MA, Peyser PA, Speliotes EK
Hum Mol Genet. 2021 30 (15): 1443-1456

PMID: 33856023 · PMCID: PMC8283205 · DOI:10.1093/hmg/ddab096

MeSH Terms (19)

Alanine Transaminase Alleles Alzheimer Disease Apolipoproteins E Databases, Genetic Exome Gene Frequency Genome-Wide Association Study Humans Liver Liver Cirrhosis Myocardial Infarction Non-alcoholic Fatty Liver Disease Obesity Phenotype Polymorphism, Single Nucleotide Prognosis Risk Factors Triglycerides

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