An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.

Brubaker DK, Kumar MP, Chiswick EL, Gregg C, Starchenko A, Vega PN, Southard-Smith AN, Simmons AJ, Scoville EA, Coburn LA, Wilson KT, Lau KS, Lauffenburger DA
Sci Signal. 2020 13 (643)

PMID: 32753478 · PMCID: PMC7459361 · DOI:10.1126/scisignal.aay3258

MeSH Terms (19)

Animals Cells, Cultured Disease Models, Animal Drug Resistance Gastrointestinal Agents Gene Expression Profiling Humans Inflammatory Bowel Diseases Infliximab Integrin alpha1 Integrins Male Mice Proteomics RNA-Seq Signal Transduction Single-Cell Analysis Species Specificity Translational Research, Biomedical

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