Lactate activation of α-cell K channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca entry.

Zaborska KE, Dadi PK, Dickerson MT, Nakhe AY, Thorson AS, Schaub CM, Graff SM, Stanley JE, Kondapavuluru RS, Denton JS, Jacobson DA
Mol Metab. 2020 42: 101056

PMID: 32736089 · PMCID: PMC7479281 · DOI:10.1016/j.molmet.2020.101056

MeSH Terms (19)

Animals Calcium Cell Line Cell Membrane Glucagon Glucagon-Secreting Cells Glucose Humans Islets of Langerhans KATP Channels Lactic Acid Male Membrane Potentials Mice Mice, Inbred C57BL Mice, Transgenic Pancreas Primary Cell Culture Pyruvic Acid

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