Antimüllerian hormone and F2-isoprostanes in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

Kim C, Slaughter JC, Terry JG, Jacobs DR, Parikh N, Appiah D, Leader B, Moravek MB, Wellons MF
Fertil Steril. 2020 114 (3): 646-652

PMID: 32682516 · DOI:10.1016/j.fertnstert.2020.04.028

OBJECTIVE - To examine whether F2-isoprostanes, a marker of systematic oxidative stress, are associated with antimüllerian hormone (AMH), an indicator of ovarian reserve, in a population-based cohort of women of black and white ethnicities.

DESIGN - Cross-sectional analysis.

SETTING - Not applicable.

PATIENTS - The CARDIA Women's Study, a population-based cohort. Black (n = 398) and white (n = 432) late reproductive-aged women (mean age 40 ± 3.6 years) without histories of gynecologic surgery.

MAIN OUTCOME MEASURES - Log-transformed serum AMH concentrations.

RESULTS - Linear regression models evaluated whether plasma F2-isoprostanes were associated with log-transformed AMH after adjustment for age, race, smoking, body mass index, and oral contraceptive pill use. Higher levels of F2-isoprostanes were associated with lower AMH levels (β -0.048 per standard deviation, 95% confidence interval -0.087, -0.01). The observed associations were stronger at younger ages (P=.04 for interaction between levels of age and F2-isoprostanes). Indicators of other steps in the oxidative stress pathway (superoxide dismutase, paraoxonase activity, oxidized low-density lipoprotein cholesterol, and carotenoids) were not associated with AMH, although lower phospholipase A2 activity (β 0.036 per standard deviation, 95% confidence interval 0.001, 0.071) was associated with lower AMH across all ages.

CONCLUSION - In a population-based cohort, higher levels of F2-isoprostanes were associated with lower ovarian reserve, particularly at younger ages.

Copyright © 2020 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

MeSH Terms (13)

Adult African Americans Age Factors Anti-Mullerian Hormone Biomarkers Cross-Sectional Studies European Continental Ancestry Group F2-Isoprostanes Female Humans Ovarian Reserve Oxidative Stress United States

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