The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice.

Georgiadou E, Haythorne E, Dickerson MT, Lopez-Noriega L, Pullen TJ, da Silva Xavier G, Davis SPX, Martinez-Sanchez A, Semplici F, Rizzuto R, McGinty JA, French PM, Cane MC, Jacobson DA, Leclerc I, Rutter GA
Diabetologia. 2020 63 (7): 1368-1381

PMID: 32350566 · PMCID: PMC7286857 · DOI:10.1007/s00125-020-05148-x

MeSH Terms (11)

Animals Blotting, Western Calcium Electrophoresis, Polyacrylamide Gel Glucose Insulin Secretion Male Mice Mice, Inbred C57BL Mice, Knockout Mitochondria

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