Cysteine depletion induces pancreatic tumor ferroptosis in mice.

Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka ZP, Hirschhorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, Olive KP
Science. 2020 368 (6486): 85-89

PMID: 32241947 · PMCID: PMC7681911 · DOI:10.1126/science.aaw9872

MeSH Terms (13)

Animals Carcinoma, Pancreatic Ductal Cationic Amino Acid Transporter 1 Cell Line, Tumor Cystathionine gamma-Lyase Cysteine Cystine Ferroptosis Gene Deletion Humans Mice Mice, Mutant Strains Pancreatic Neoplasms

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