infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.

Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D
Proc Natl Acad Sci U S A. 2020 117 (14): 8064-8073

PMID: 32198200 · PMCID: PMC7149309 · DOI:10.1073/pnas.1915255117

MeSH Terms (17)

Animals Bacterial Proteins Bacterial Toxins Cells, Cultured Clostridioides difficile Clostridium Infections Colon Disease Models, Animal Female Frizzled Receptors Humans Intestinal Mucosa Mice Organoids Primary Cell Culture Recombinant Proteins Stem Cells

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