Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning.

Penn WD, McKee AG, Kuntz CP, Woods H, Nash V, Gruenhagen TC, Roushar FJ, Chandak M, Hemmerich C, Rusch DB, Meiler J, Schlebach JP
Sci Adv. 2020 6 (10): eaay7505

PMID: 32181350 · PMCID: PMC7056298 · DOI:10.1126/sciadv.aay7505

MeSH Terms (15)

Cell Membrane Gene Expression HEK293 Cells Humans Hydrophobic and Hydrophilic Interactions Lipid Bilayers Models, Molecular Mutation Protein Domains Protein Folding Protein Structure, Secondary Recombinant Proteins Rhodopsin Solubility Thermodynamics

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