Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review.

Perry WJ, Weiss A, Van de Plas R, Spraggins JM, Caprioli RM, Skaar EP
Curr Opin Chem Biol. 2020 55: 127-135

PMID: 32087551 · PMCID: PMC7237308 · DOI:10.1016/j.cbpa.2020.01.008

Metals play an essential role in biological systems and are required as structural or catalytic co-factors in many proteins. Disruption of the homeostatic control and/or spatial distributions of metals can lead to disease. Imaging technologies have been developed to visualize elemental distributions across a biological sample. Measurement of elemental distributions by imaging mass spectrometry and imaging X-ray fluorescence are increasingly employed with technologies that can assess histological features and molecular compositions. Data from several modalities can be interrogated as multimodal images to correlate morphological, elemental, and molecular properties. Elemental and molecular distributions have also been axially resolved to achieve three-dimensional volumes, dramatically increasing the biological information. In this review, we provide an overview of recent developments in the field of metal imaging with an emphasis on multimodal studies in two and three dimensions. We specifically highlight studies that present technological advancements and biological applications of how metal homeostasis affects human health.

Copyright © 2020 Elsevier Ltd. All rights reserved.

MeSH Terms (12)

Animals Biosensing Techniques Coenzymes Homeostasis Humans Mass Spectrometry Metalloproteins Metals Models, Theoretical Molecular Imaging Multimodal Imaging Optical Imaging

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