A new type of transforming growth factor-beta, TGF-beta 3.

Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ
EMBO J. 1988 7 (12): 3737-43

PMID: 3208746 · PMCID: PMC454948

A new type of TGF-beta, TGF-beta 3, has been identified by cDNA characterization. The amino acid sequence of mature TGF-beta 3 and its precursor has been derived from porcine and human cDNA sequences. The human TGF-beta 3 gene is spread over seven exons as in the case of the TGF-beta 1 gene. Comparison with TGF-beta 1 and -beta 2 indicates a strong conservation of the mature sequences, but a relaxed homology in the precursor segments. TGF-beta 3 mRNA is mainly expressed in cell lines from mesenchymal origin, suggesting a biological role different from the other TGFs-beta.

MeSH Terms (14)

Amino Acid Sequence Animals Base Sequence Blotting, Northern Cloning, Molecular DNA Genes Humans Introns Molecular Sequence Data Protein Precursors RNA, Messenger Swine Transforming Growth Factors

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