Optimization of a transmit/receive surface coil for squirrel monkey spinal cord imaging.

Lu M, Wang F, Chen LM, Gore JC, Yan X
Magn Reson Imaging. 2020 68: 197-202

PMID: 32087231 · PMCID: PMC7136156 · DOI:10.1016/j.mri.2020.02.011

MR Imaging the spinal cord of non-human primates (NHP), such as squirrel monkey, is important since the injuries in NHP resemble those that afflict human spinal cords. Our previous studies have reported a multi-parametric MRI protocol, including functional MRI, diffusion tensor imaging, quantitative magnetization transfer and chemical exchange saturation transfer, which allows non-invasive detection and monitoring of injury-associated structural, functional and molecular changes over time. High signal-to-noise ratio (SNR) is critical for obtaining high-resolution images and robust estimates of MRI parameters. In this work, we describe our construction and use of a single channel coil designed to maximize the SNR for imaging the squirrel monkey cervical spinal cord in a 21 cm bore magnet at 9.4 T. We first numerically optimized the coil dimension of a single loop coil and then evaluated the benefits of a quadrature design. We then built an optimized coil based on the simulation results and compared its SNR performance with a non-optimized single coil in both phantoms and in vivo.

Copyright © 2020 Elsevier Inc. All rights reserved.

MeSH Terms (12)

Animals Cervical Cord Diagnostic Tests, Routine Diffusion Tensor Imaging Equipment Design Magnets Multiparametric Magnetic Resonance Imaging Neck Phantoms, Imaging Saimiri Signal-To-Noise Ratio Spinal Cord

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