Responsiveness of iliac collateral vessels to constrictor stimuli in atherosclerotic primates.

Lopez JA, Armstrong ML, Harrison DG, Piegors DJ, Heistad DD
Circ Res. 1988 63 (6): 1020-8

PMID: 3197270 · DOI:10.1161/01.res.63.6.1020

This study was performed to examine, first, the protective effects and responses of collateral vessels of the hind limb in normal and atherosclerotic monkeys and, second, the effects of chronic arterial occlusion on the development of atherosclerosis. The iliac artery was ligated on one side in cynomolgus monkeys. Sixteen months later, we recorded the pressure gradient across the limb collaterals and measured blood flow with microspheres. Collateral conductance was fivefold greater after chronic ligation of the iliac artery than after acute ligation. Despite dilatation or growth of collateral vessels after chronic ligation, iliac pressure was reduced distal to the ligation. Blood flow to the limb was normal after chronic ligation in both normal and atherosclerotic monkeys. Collateral vessels constricted in response to infusion of phenylephrine and serotonin in normal and atherosclerotic monkeys. Thus, one conclusion of this study is that collateral vessels restore limb blood flow to normal after chronic vascular occlusion in both normal and atherosclerotic monkeys, but the protective effects of collateral vessels may be compromised by vasoconstrictor stimuli. Morphometric measurements indicated that occlusion of the iliac artery reduced proliferation of atherosclerotic intima distal to the occlusion in the cholesterol-fed monkeys. Thus, a second conclusion of this study is that atherosclerosis is attenuated below an arterial occlusion.

MeSH Terms (13)

Animals Arteriosclerosis Blood Pressure Blood Vessels Collateral Circulation Hindlimb Iliac Artery Ligation Macaca fascicularis Male Phenylephrine Regional Blood Flow Serotonin

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